Journal article
Altered brain activity in unipolar depression unveiled using connectomics
RFH Cash, VI Müller, PB Fitzgerald, SB Eickhoff, A Zalesky
Nature Mental Health | Published : 2023
Abstract
Over 20 years of neuroimaging experiments into aberrant task-based brain activity in unipolar depression have failed to reliably delineate a convergent set of anatomical regions. Here we examined whether study-derived coordinates might delineate a dysfunctional brain network in unipolar depression rather than isolated neuroanatomical foci, utilizing data from 57 studies with 99 individual neuroimaging task-based experiments, testing either emotional or cognitive processing (n = 1,058). We further assessed clinical relevance by computing optimal network-based personalized targets in 26 individuals who previously received transcranial magnetic stimulation for unipolar depression. Although coor..
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Grants
Awarded by Brain and Behavior Research Foundation
Funding Acknowledgements
We thank S. Siddiqi for providing the convergent and lesion circuits. We thank all participants, nurses and staff involved in the collection of clinical data. We thank all who contributed to the original experiments from which the present coordinates are derived and those involved in the Human Connectome Project. We thank all the funding bodies below, and note that the funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. R.F.H.C. was funded by the Australian Research Council (DE200101708) and Brain and Behavior Research Foundation. A.Z. was supported by the Australian National Health and Medical Research Council Senior Research Fellowship B (ID: 1136649). P.B.F. has received equipment for research from Cervel Neurotech, Medtronic, MagVenture A/S and Brainsway. S.B.E. acknowledges funding by the European Union's Horizon 2020 Research and Innovation Program (grant agreements 945539 (HBP SGA3) and 826421 (VBC), the Deutsche Forschungsgemeinschaft (DFG), Project-ID 431549029 - SFB 1451) and the National Institute of Health (NIH, 2R01-MH074457).